Building DNA Gizmo Worksheet Directions: Complete the following activities using the Building DNA Gizmo. Students color each nucleotide and paste them in an anti-parallel orientation. Learn how each component fits into a DNA molecule, and see how a unique, self-replicating code can be created. They can also serve as an excellent jumping-off point for more complex biological topics. Your finished model should resemble a ladder. DNA can be a complex topic, but these hands-on, fun activities and games can make it easier to understand. Students should already have an understanding of DNA structure. Although each human has a unique DNA sequence, the DNA in all of us is about 99.9% identical! During replication, double-stranded DNA unwinds and each strand acts as a template for a new strand. This worksheet will be turned in as sample work at the end of this lesson. See next page. Build: Follow the steps given in the Gizmo to construct a molecule of DNA. Task Card: Building DNA . 6) Complete the left side of the DNA ladder by adding complementary nucleotides or nucleotides that fit. Worksheet has space for pasting the completed model and a few questions regarding the base-pair rule, and the composition of a nucleotide. This task card can be used for remote learning or in class as a small group or individual activity. The Twizzler will be the Backbones. Student Exploration: Building DNA Vocabulary: double helix, DNA, enzyme, mutation, nitrogenous base, nucleoside, nucleotide, replication Prior Knowledge Questions (Do these BEFORE using the Gizmo.) 1. Before mitosis begins, a cell doubles its amount of chromosomes by replicating, or copying all of its DNA. This simple activity asks students to cut out shapes of nucleotides, each having a phosphate, a base, and a deoxyribose sugar. Making a Model of DNA 5) Construct the right side of your DNA molecule by putting together in sequence a cytosine, thymine, guanine and adenine nucleotide.See next page. In this activity, you will use pieces of candy to make a model for a short section of DNA—enough to get a sense of what DNA is like and how it encodes life. 4. (Note: For simplicity, this DNA molecule is shown in two dimensions, without the twist.) The marshmallows will be the Bases. DNA bases form pairs in specific ways. Best For: Biology Adenine (A) always pairs with Thymine (T). Use colored marshmallows, Twizzler and toothpicks to construct a DNA Double Helix. DNA molecules contain instructions for building every living organism on Earth, from the tiniest bacterium to a massive blue whale. Activity A: Build a DNA molecule Get the Gizmo ready: If necessary, click Reset to start the building process. A nucleoside consists of two parts: a pentagonal sugar called deoxyribose and a nitrogenous base that is shown in color. Warm Up There are two DNA components shown in this Gizmo: nucleosides and phosphates. Question: What is the structure of DNA? Guanine (G) always pairs with Cytosine (C). DNA is an incredible molecule that forms the basis of life on Earth. Durin... (more) g this activity students will describe DNA replication in three different ways - steps, components and overall process. https://www.biointeractive.org/classroom-resources/modeling-structure-dna Building DNA and RNA. Construct a DNA molecule, examine its double-helix structure, and then go through the DNA replication process.

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